I use mpd and ncmpc++, myself. My library got too large (Just shy of 70,000 songs now) and all the GUI players choke and freeze when I try to scan my library, including Rhythmbox and QuodLibet. I’m kind of interested in how inori develops, since ncmpc++ isn’t getting any active development beyond fixing bugs when things break with updates, but I’m also pretty happy with it for now.
Gonic works pretty well with my library, and Tempo is fine for a client. I mostly just put stuff on an SD card in my Fiio these days, though.